Instagram Video Odin Lloyd Confederations Cup russell brand conundrum Alex Minsky christina aguilera
Tuesday, June 25, 2013
Rainy Day Staycation at Parque Espa?a Residence Hotel ...
With the kids back to school and the rainy days upon us, it?s hard to squeeze in a getaway. But what if stress is getting the best of you? Then the next best thing would be to go on a ?staycation?.
A staycation is basically having a mini ?vacation? either just within the metro ? usually staying in a hotel/bed and breakfast/resort ? or somewhere that is just a couple of hours drive from where you live.?
However, if you?re so fed up with the metro and want a change of scenery but you?re just not up for more than a 3-hour drive to Tagaytay or Batangas, your next best bet will be to head just a little bit down south to Alabang.
Located in a quieter area of Filinvest City is Parque Espa?a. Unlike most hotels, it is a serviced residence that will be your home away from home.As soon as you step in, your attention will be caught by the colorful Mediterranean tiles of the front desk and the vibrantly-colored furnishings of Dolce Y Naturales at the lobby lounge that is perfectly balanced by the earth-toned accents. Tr?s chic!
I approached the front desk to inform of my reservation, and after presenting? a valid ID and handing over a Php1,000 incidental deposit (refundable upon check-out), I was given our keycard together with 2 breakfast vouchers and WiFi passwords*.
We were given a 55 square meter 1-Bedroom Deluxe. Needless to say, my mom and I had a lot of space to move around!
Now, don?t worry if the lobby?s theme is not carried through to the rooms yet (but that?s not to say it?s not stylish or cozy). Parque Espa?a?s Sales & Marketing Manager, Tina Robles Anciano, explains that renovation of some rooms are in the works.
Modest dining table complete with dining ware and complimentary bottles of water.
Living room accent and flat screen TV
And because it is a serviced residence, you literally have everything you?ll ever going to need. It has a living area, dining table good for 4 persons, a kitchenette and more.
Our comfy queen-sized bed for the night
We had a bed that was more than big enough for us. The clean, fluffy and comfy sheets and pillows sent us to dreamland in no time.
Aside from the TV in the living room, there is also a wall-mounted flat screen TV and DVD player in the room.
And to maximize space ? as if the room?s not spacious enough ? the closet?s sliding door doubles as a full-length mirror. Inside are built-in clothes? hanger and a safe to keep your valuables.
The working desk with iPod dock/alarm clock and the room?s own WiFi router for faster browsing experience.
The spotless toilet and bath. Plus points for the glass-enclosed shower. No wet floors here.
Each room has its own fully-equipped kitchenette with a fridge, stove, microwave oven, and tea and coffee-making facilities. It even has a flat iron and provision for washing machine.
While I?m sure it?ll be hard to leave the comforts of your room, the roof deck is worth checking out primarily because of the modest pool and the view.
Refreshing view, isn?t it?
This is the beauty of Alabang: you get to enjoy the laid back vibe of the south and be in the metro at the same time.
If you need a quick fix, Westgate and Commerce Center is just a stone throw?s away, but why go out when you can dine at their in-house restaurant? Also located at the roof deck is Bistro del Cielo which serves really, really (did I say really?) good? and affordable food. And I?m not even exaggerating. The food is so delectable it deserves a separate blog post. ;)
For the shopaholics, guests can take advantage of Parque Espa?a?s FREE 24-hour shuttle service to nearby malls like Festival Mall and Alabang Town Center. Talk about value-added service!
Executive Suite
One of the rooms of the 3-bedroom Deluxe. Perfect for groups or families.
The staff was also kind enough to show me the other rooms they have. Though the rooms vary in layout, the amenities are consistent.
For the fitness buff, Parque Espa?a?s location is perfect for a morning run. And don?t worry if it?s gloomy outside, you can still use their fitness center located at the ground floor.?
K*WiFi is Php100.00 per password
For real time travel updates and more photos, please 'Like' my Facebook page and follow me on Twitter. Happy travels!
Source: http://www.excursionista.net/2013/06/parque-espana-hotel.html
Hurricane Sandy update ellen degeneres tomb of the unknown soldier tomb of the unknown soldier HMS Bounty dominion power Heather Clem
Top China paper hits back at U.S. accusations on Snowden
BEIJING (Reuters) - China's top state newspaper praised fugitive U.S. spy agency contractor Edward Snowden on Tuesday for "tearing off Washington's sanctimonious mask" and rejected accusations that it had facilitated his departure from Hong Kong.
The strongly worded front-page commentary in the overseas edition of the People's Daily, the official newspaper of the Chinese Communist Party, comes after Washington harshly criticized Beijing for allowing Snowden to flee.
The exchanges mark a deterioration in ties between the two countries just weeks after a successful summit meeting between President Barack Obama and President Xi Jinping. But experts say Washington is unlikely to resort to any punitive action.
The White House said the decision was "a deliberate choice by the government to release a fugitive despite a valid arrest warrant, and that decision unquestionably has a negative impact on the U.S.-China relationship.
The People's Daily, which reflects official thinking of the government, said China could not accept "this kind of dissatisfaction and opposition".
The Chinese government has said it was gravely concerned by Snowden's allegations that the United States had hacked into many networks in Hong and China, including Tsinghua University, which hosts one of the country's Internet hubs, and Chinese mobile network companies. It has said it had taken the issue up with Washington.
"Not only did the U.S. authorities not give us an explanation and apology, it instead expressed dissatisfaction at the Hong Kong Special Administrative Region for handling things in accordance with law," wrote Wang Xinjun, a researcher at the Academy of Military Science in the People's Daily commentary.
"In a sense, the United States has gone from a 'model of human rights' to 'an eavesdropper on personal privacy', the 'manipulator' of the centralized power over the international Internet, and the mad 'invader' of other countries' networks," the People's Daily said.
"The world will remember Edward Snowden," the newspaper said. "It was his fearlessness that tore off Washington's sanctimonious mask."
In another commentary in the Global Times, owned by the People's Daily, the newspaper also attacked the United States for cornering "a young idealist who has exposed the sinister scandals of the U.S. government".
"Instead of apologizing, Washington is showing off its muscle by attempting to control the whole situation," the Global Times said.
(Reporting by Sui-Lee Wee; Editing by Raju Gopalakrishnan)
Source: http://news.yahoo.com/top-china-paper-hits-back-u-accusations-snowden-040824725.html
bonnie raitt internal revenue service intc tupac andrew shaw hologram pulitzer prize winners
Monday, June 17, 2013
New drug reverses loss of brain connections in Alzheimer's
June 17, 2013 ? The first experimental drug to boost brain synapses lost in Alzheimer's disease has been developed by researchers at Sanford-Burnham Medical Research Institute. The drug, called NitroMemantine, combines two FDA-approved medicines to stop the destructive cascade of changes in the brain that destroys the connections between neurons, leading to memory loss and cognitive decline.
The decade-long study, led by Stuart A. Lipton, M.D., Ph.D., professor and director of the Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, who is also a practicing clinical neurologist, shows that NitroMemantine can restore synapses, representing the connections between nerve cells (neurons) that have been lost during the progression of Alzheimer's in the brain. The research findings are described in a paper published June 17 by the Proceedings of the National Academy of Sciences (PNAS).
The focus on a downstream target to treat Alzheimer's, rather than on amyloid beta plaques and neurofibrillary tangles -- approaches which have shown little success -- "is very exciting because everyone is now looking for an earlier treatment of the disease," Lipton said. "These findings actually mean that you might be able to intercede not only early but also a bit later." And that means that an Alzheimer's patient may be able to have synaptic connections restored even with plaques and tangles already in his or her brain.
Targeting lost synapses
In their study, conducted in animal models as well as brain cells derived from human stem cells, Lipton and his team mapped the pathway that leads to synaptic damage in Alzheimer's. They found that amyloid beta peptides, which were once thought to injure synapses directly, actually induce the release of excessive amounts of the neurotransmitter glutamate from brain cells called astrocytes that are located adjacent to the nerve cells.
Normal levels of glutamate promote memory and learning, but excessive levels are harmful. In patients suffering from Alzheimer's disease, excessive glutamate activates extrasynaptic receptors, designated eNMDA receptors (NMDA stands for N-methyl-D-aspartate), which get hyperactivated and in turn lead to synaptic loss.
How NitroMemantine works
Lipton's lab had previously discovered how a drug called memantine can be targeted to eNMDA receptors to slow the hyperactivity seen in Alzheimer's. This patented work contributed to the FDA approval of memantine in 2003 for the treatment of moderate to severe Alzheimer's disease. However, memantine's effectiveness has been limited. The reason, the researchers found, was that memantine -- a positively charged molecule -- is repelled by a similar charge inside diseased neurons; therefore, memantine gets repelled from its intended eNMDA receptor target on the neuronal surface.
In their study, the researchers found that a fragment of the molecule nitroglycerin -- a second FDA-approved drug commonly used to treat episodes of chest pain or angina in people with coronary heart disease -- could bind to another site that the Lipton group discovered on NMDA receptors. The new drug represents a novel synthesis connecting this fragment of nitroglycerin to memantine, thus representing two FDA-approved drugs connected together. Because memantine rather selectively binds to eNMDA receptors, it also functions to target nitroglycerin to the receptor. Therefore, by combining the two, Lipton's lab created a new, dual-function drug. The researchers developed 37 derivatives of the combined drug before they found one that worked, Lipton said.
By shutting down hyperactive eNMDA receptors on diseased neurons, NitroMemantine restores synapses between those neurons. "We show in this paper that memantine's ability to protect synapses is limited," Lipton said, "but NitroMemantine brings the number of synapses all the way back to normal within a few months of treatment in mouse models of Alzheimer's disease. In fact, the new drug really starts to work within hours."
To date, therapies that attack amyloid plaques and neurofibrillary tangles have failed. "It's quite disappointing because I see really sick patients with dementia. However, I'm now optimistic that NitroMemantine will be effective as we advance to human trials, bringing new hope to both early and later-stage Alzheimer's patients," Lipton said.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/vWfGxSNdZ4Y/130617160849.htm
21 jump street illinois primary results acapulco mexico hines ward robert deniro mexico news the talented mr ripley
Black Butler: Next Chapter
Oh, may I please reserve Ciel? My favorite movie would be, um, oh I have no idea. I love them all. XD
</3
Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/KtHW-QkpQOA/viewtopic.php
UFC 151 empire state building prince harry Hurricane hunger games Joey Kovar Expendables 2
Glasses-Free 3D and Smell-o-Vision: Movies of the Future from 1935
Predictions that 3D movies would be the wave of the future are even older than the talkies
The October 1935 issue of Everyday Science and Mechanics magazine included an article by editor-in-chief Hugo Gernsback. The article outlined the progress that had been made in technologies like the telephone, the locomotive and the radio and looked to the future of movies. Specifically, the future of 3D movies?coming soon with smell-o-vision!
What is the next step? Obviously, the three-dimensional or stereoscopic motion picture. All films thrown on the screen today are flat; they do not stand out as does, for instance, a stereoscopic picture. The characters move in but two dimensions, whereas they should move in three. In order to heighten the illusion of the motion picture, the characters must seem to stand from the screen. It is true, stereoscopic motion pictures have already been produced many times, but not satisfactorily, because you require a special set of eyeglasses to view them, and this is a bad stumbling block. No audience will stand for this indefinitely. Science, no doubt, will solve this problem so that, with the bare and unaided eye, you will see three-dimensional motion pictures. I am certain that the problem will be solved satisfactorily during the next ten years.
Gernsback believed that the evolution of movies was almost pre-determined in its path towards more realism. He argued that color film was making great strides and that it would soon be a mainstream reality in theaters around the world. But what makes a film ostensibly more "real" picture is one of the great movie debates that has been waged since the dawn of the medium?and we still can't decide what it means here in the 21st century. What is the goal of the movies? Is it to create a perfect depiction of reality? And how do we define that reality?
After that, what? It should be noted that, after all, motion pictures are only an illusion. While you view the screen you know all the time that you are not looking at living characters; but, the closer the art comes to this and the more perfect the illusion, the greater will be the acclaim by the public.
What further illusion can we have from motion pictures? We can now hear them, as well as see them in colors. It is too much to hope to feel them but, anyway, the three-dimensional movie will not make this necessary. Obvious- ly, we cannot hope to taste them. One other sense is left open, and that is scent. And here the technicians during the next twenty years will no doubt evolve marvels.
This would be done by "scent organs" from which pipes a r e carried through the auditorium; then, by forced draft, the various scents could be wafted over the house to the delight of the audience. Some years ago, in a New York theatre, a musical comedy had an elaborate scene of an orange grove.
The idea that smells would one day be their own entertainment certainly predates this prediction from Gernsback, but this is the earliest instance of incorporating smell machines with movies of the future that I've ever come across.
Today, you need look no further than Disneyland to find the "smellitizers" that accompany 3D movies like It's Tough to Be A Bug! and MuppetVision 3D. Outside Disneyland you can even get all the ambient thrills of various 4D movie technologies with not only smell-o-vision, but back ticklers
Of course, glasses-free 3D
Image: 1930, Getty Images "Lord Ossulston operates the cinema projector in the cinema opened on his estate."
Source: http://paleofuture.gizmodo.com/glasses-free-3d-and-smell-o-vision-movies-of-the-futur-513784216
meteor shower Al Michaels Canelo vs Trout 420 Meteor Showers 2013 Darrelle Revis david ortiz
North Korea wants to hold high-level talks with U.S.
By Jane Chung
SEOUL (Reuters) - North Korea on Sunday offered high-level talks with the United States to ease tensions on the Korean peninsula, only days after it canceled planned official talks with South Korea for the first time in over two years.
Planned high-level talks between North and South Korea were scrapped last week after the North abruptly called off the talks. The North blamed the South for scuttling discussions that sought to mend estranged ties between the rival Koreas.
North Korea National Defence Commission in a statement carried by KCNA news agency on Sunday said Washington can pick a date and place for talks and the two sides can discuss a range of issues, but no preconditions should be attached.
"In order to ease tensions on the Korean peninsula and to achieve regional peace and safety, we propose to hold high-level talks between the DPRK and the United States, " said the spokesman for the North's National Defence Commission in the statement. North Korea's official name is the Democratic People's Republic of Korea (DPRK).
"If the U.S. is truly interested in securing regional peace and safety and easing tensions, it should not mention of preconditions for the talks," the statement said.
Earlier this year, North Korea threatened nuclear and missile strikes against South Korea and the United States after it was hit with U.N. sanctions for its February nuclear weapons test.
In the statement, Pyongyang reiterated it was willing to discuss disarmament but the world should also be denuclearized including its southern neighbor. It added it wants the United States to sign a formal peace treaty formally ending the 1950-53 Korean War that divided the two Koreas.
Korea was divided after the Second World War and when the Korean War ended in an armistice rather than a permanent peace treaty, leaving the two countries technically at war.
North Korea agreed a denuclearization-for-aid deal in 2005 but later backed out of that accord. It has said its nuclear arms are a "treasured sword" that it will not abandon.
North Korea's one major diplomatic ally, China, has urged Pyongyang to abandon its nuclear weapons program and return to talks.
The North has a long record of making threats to secure concessions from the United States and South Korea.
North Korea's 30-year-old leader, Kim Jong-un, took power in December 2011 and has since carried out two long-range rocket launches and a nuclear weapons test, as well as a campaign of threats against South Korea and the United States.
Threats have waned in the past month, showing signs of easing tensions such as proposing talks with South Korea in early June. The talks had been intended to discuss issues resuming operations of joint commercial projects and families split during the 1950-53 Korean War.
(Reporting By Jane Chung, Editing by Jack Kim, Michael Perry)
Source: http://news.yahoo.com/north-korea-proposes-high-level-talks-u-kcna-014322264.html
platypus overboard east of eden weather radio indiana autoimmune disease news channel 9
Subscribe to:
Posts (Atom)